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Pleiotropic effects of some anti-inflammatory drugs used in the treatment of osteoarthritis
Summary. A differentiated approach to the treatment of patients with osteoarthritis (OA) has always been a complex problem. In respect that patients with OA usually are over the age of 40 years, and therefore have not a single comorbid disease, which greatly complicates the choice of effective treatment. The article presents the effectiveness of the most commonly used drugs used in the treatment of patients with OA: nonsteroidal anti-inflammatory drugs (diclofenac, nimesulide, meloxicam) and symptomatic slow-acting anti-inflammatory drugs (chondroitin sulfate, glucosamine sulfate, diacerein, ginger root extract, avocado soybean unsaponifiables), as well as their influence on the indices of purine, carbohydrate, lipid metabolism and the possibility of their safe use in person with concomitant pathology.
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