Eosinophilic granulomatosis with polyangiitis: a multidisciplinary approach to diagnosis and treatment based on a clinical case study

Orlova I.V.¹, Shkolina N.V.², Vovk I.I.², Shapoval I.I.¹, Stanislavchuk M.A. ¹

• ¹Vinnytsia National Medical University named after M.I. Pirogov, Vinnytsia
• ²KNP «Vinnytsia Regional Clinical Hospital named after M.I. Pirogov» of Vinnytsia Regional Council, Vinnytsia

Summary. The article presents a representative clinical case of a patient with eosinophilic granulomatosis with polyangiitis (EGPA), the course of which was characterised by typical but varied symptoms. Despite the presence of recurrent respiratory infections, pulmonary infiltrates, peripheral neuropathy, hypereosinophilia, and weight loss, the correct diagnosis was made with a significant delay. Over the course of several months, the patient was examined by specialists of various profiles, but systemic vasculitis was not recognised in a timely manner. Only after repeated hospitalisations and progression of symptoms did the patient see a rheumatologist. Based on clinical manifestations, laboratory changes, and instrumental examination data, as well as compliance with the ACR/EULAR 2022 classification criteria, a diagnosis of EGPA was established. The prescription of adequate therapy, namely combined treatment with glucocorticoids and immunosuppressants, ensured a gradual decrease in disease activity and remission. Similar clinical cases emphasise the importance of increasing awareness of systemic vasculitis among doctors of various specialities. Early recognition of characteristic signs, timely referral to a rheumatologist, and initiation of therapy are key factors in avoiding complications and improving the prognosis for patients with EGPA.