EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS INVOLVING PERIPHERAL NERVOUS SYSTEM: A CASE REPORT AND LITERATURE REVIEW
Summary. Eosinophilic granulomatosis with polyangiitis (EGPA, formerly called «Churg-Strauss syndrome») is a rare variant of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. It is characterized by a combination of vasculitic and eosinophilic manifestations, requiring targeted therapy, which is somewhat different from the treatment of other types of vasculitis in this group. This article describes a clinical case of exacerbation of EGPA in a 57-year-old patient with a predominant lesion of the peripheral nervous system in the form of multiple mononeuritis. The phases of EGPA, and restoration of the lost function of the peripheral nervous system are described, as well as the course of coronavirus disease during treatment with glucocorticoids and cyclophosphamide. Our own data on the frequency of nervous system damage in patients with ANCA-associated vasculitis are presented. Approaches to the differential diagnosis of hypereosinophilic conditions are disclosed using the example of this patient, the differences between the recommendations of the American College of Rheumatology (ACR) (2021) and the European League Against Rheumatism/European Renal Association — European Dialysis and Transplant 2016) on the management of EGPA are analyzed. The new ACR/EULAR 2022 classification criteria of this disease are considered.
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