Changes in serum uric acid levels due to coronavirus disease

Sydorova A.O.1, Iaremenko O.B.2

Summary. Changes in specific biochemical parameters can predict the severity of COVID-19. Considering that uric acid (UA) has antioxidant properties, changes in its level during coronavirus disease could correlate with the severity of its course. Objectives. To study the relationship between the severity of COVID-19 and the serum level of UA when patients were admitted to the hospital in 2020 and 2021. Materials and methods. This retrospective single-center study included 63 hospitalized patients in 2020, and 150 patients in 2021 with a PCR-confirmed diagnosis of COVID-19. The level of UA was compared with 40 people without COVID-19 (control group). The correlation of the UA level with the patient’s age and some laboratory markers upon admission to the hospital was determined. Results. The average level of UA in patients with coronavirus disease was 299.2±121.9 µmol/l in 2020 (p>0.05 vs control group); in 2021 it was significantly lower — 251.5±104.1 µmol/l (p<0.05 vs 2020, p<0.001 vs control group). In 2020 and 2021, no relationship was found between the UA level and the coronavirus disease’s severity. At both year points, a correlational dependence of the UA level on the age of the patients was observed, but no correlation was found with laboratory markers of the severity of the course of the disease. Conclusions. Hypouricemia is a widespread laboratory finding in patients with COVID-19 but is not a prognostic factor for severe illness. The lower level of UA in 2021 compared to 2020 could probably be associated with different properties of the coronavirus strains circulating in these years.

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