Association of lipid metabolism parameters and lipid ratios with serum uric acid levels in patients with stable ischemic heart disease: a single-center, cross-sectional study
Summary. The objective of this study was to determine the association of lipid metabolism parameters and lipid ratios with serum uric acid (sUA) levels in patients with stable ischemic heart disease (IHD). Patients and methods. We conducted a single-center, cross-sectional study of 63 patients with stable IHD (41 (65.1%) men and 22 (34.9%) women, median age — 63 years). They were divided into 2 groups according to the presence (n=21) or absence (n=42) of hyperuricemia (HU). The plasma total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apolipoproteins A1 (apoA1) and B (apoB) concentrations were measured. The low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-С) and non-high-density lipoprotein cholesterol (non-HDL-C) were calculated. Also some lipid indices were computed, including the Atherogenic Coefficient (AC), Castelli Risk Indices I and II (CRI-I, CRI-II), Atherogenic Index of Plasma (AIP), etc. Results. In IHD patients with HU significantly higher levels of TC, TG, VLDL-С, non-HDL-C, lower concentration of apoA1 as well as higher AC, CRI-I, CRI-II, AIP, TG/HDL-C ratio and apoB/apoAl ratio were observed. Univariate analysis revealed statistically significant moderate correlation between sUA concentration and levels of TG, VLDL-С, apoA1, AC, CRI-I, AIP, TG/HDL-C ratio, VLDL-С/TC ratio, and weak correlation between sUA concentration and HDL-C level. Conclusions. The course of stable IHD in patients with HU was characterized by pro-atherogenic changes in lipid metabolism. Also the association of lipid metabolism parameters with sUA concentration was revealed. It indicates a higher risk for atherosclerosis progression among these patients.
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