The adipokine levels in patients with rheumatoid arthritis, its association with the course of the disease and damage of the cardiovascular system

Shevchuk S.V.¹, Galyutina O.Yu.², Segeda U.S. ²

• ¹National Pirogov Memorial Medical University, Vinnytsya
• ²Науково-дослідний інститут реабілітації інвалідів (навчально-науково-лікувальний комплекс) Вінницького національного медичного університету ім. М.І. Пирогова

Summary. Summary. The purpose of the study was to investigate the serum concentration of leptin and adiponectin in patients with rheumatoid arthritis (RA) and to determine their association with the course of the disease and subclinical manifestations of atherosclerotic vascular involvement. It has been established that patients with RA had dysadipokinemia, a decrease in adi­ponectin levels (by 52%) and a growth of leptin (40%), compared with practically healthy individuals. Serum adipokine level was associated with age and lipid metabolism disorders and did not depend on sex, duration of the disease, and body mass index. The main causes of dysadipokinemia in patients with RA are high levels of activity (C-reactive protein, tumor necrosis factor-alpha, DAS28). Also, adipokine levels are associated with structural and functional changes of vessels in RA patients, since the thickening of intima-media complex of the common carotid artery and the reduction of endothelial-dependent vasodilation were more common among individuals with low levels of adiponectin and high leptin than in patients with normal adipokine values.