Assessment of disease activity in adult patients with juvenile idiopathic arthritis in history

Dzhus M.B.

Summary. Summary. Diagnostic value of DAS28 and JADAS scales was evaluated in article in the purpose of the feasibility of their use in adult patients with different variants of JIA. The study involved 124 adult patients with a different ILAR-variants of JIA history regardless of the presence or absence of active inflammation at the time of inspection. The assessment of disease activity was carried out simultaneously in all patients using DAS28 and JADAS scales. In the analysis of disease acti­vity were taken into account indicators showed extreme points — remission and high disease activity. The last is known as a poor prognostic marker and requires intensification of therapy and appointment of biological treatment. Ranking disease activity results scored by DAS28 and JADAS scales a significant underestimation determining both remission and high disease activity was detected by DAS28 scale. Our results match with other studies supporting the view that the scale JADAS, designed to assess the activity of JIA in childhood, which included count in other joints (including cervical spine, ankle and hip joints) is more sensitive han DAS28 in adulthood to determine the extreme points in the treatment process JIA — high activity and remission. Therefore, in order not to lose patients with active JIA in adulthood, use of JADAS scale, instead of DAS28, to assess the activity of JIA is recommended. Adult rheumatologist should consider the age of onset of articular syndromes. In early juvenile articular process or in the transition patients from pediatric to adult health care service disease activity should be evaluated by measuring JADAS scale instead of widely used in adult practice DAS28 scale.

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