RHEUMATOID ARTHRITIS: THE SEARCH FOR NEW TREATMENT STRATEGIES
Delva Yu.V., Yatsyshyn R.I., Drogomeretska O.I., Babenko О.І.
Summary. The future of innovative therapeutic methods for the treatment of RA opens up great potential for patients who do not respond sufficiently to modern treatment methods. Cell therapy technologies, RNA therapy, nanotechnology, gene editing technology, and others open up tempting prospects for improving the results of treatment of the disease. Deepening knowledge about the pathogenesis and nature of RA, progress in medical research opens up opportunities for the identification of biomarkers, prognostic indicators regarding the course of the disease and the implementation of personalized medicine in the treatment of RA, taking into account the RA phenotype to prescribe a rational individual treatment strategy to specific patients. It is necessary to continue the work of scientists and clinicians to find new solutions. The review highlights the latest work of scientists on the development of new promising technologies and strategies for the treatment of RA, which will ultimately help to achieve effective control over the disease. The purpose of the study: to highlight the main directions of searching for promising technologies and approaches in the treatment of RA in the light of new data obtained by scientists recently. Materials and methods. The scientific and methodological literature in the PubMed, ELSEVIER, Google Scholar databases for 2014–2024 was analyzed with the selection of the most relevant information. The search was conducted using the relevant keywords: rheumatoid arthritis; innovative technologies; personalized medicine; treatment strategy. The results. This review presents current data on cell therapy technologies, RNA therapy, nanotechnology, gene editing technology and others, which open up promising prospects for improving the results of RA treatment. Conclusions. It is necessary to continue the work of scientists and clinicians to search, develop and implement new approaches and strategies in the treatment of RA. The most attractive prospect in the treatment of RA would be the restoration of immune tolerance in patients.
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