NON-HODGKIN’S LYMPHOMA IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: PROBLEMS OF DIAGNOSIS ON THE EXAMPLE OF A CLINICAL CASE
Summary. The high frequency of development of lymphoproliferative diseases in patients with systemic lupus erythematosus (SLE) creates a problem of their diagnosis. SLE is a serious disease with many clinical manifestations that can mask not only the initial symptoms of non-Hodgkin’s lymphoma (NL), but also become an obstacle to its detection even in the terminal stage. Aim. To describe the problems of diagnosis of NL in patients with SLE using the example of a clinical case. Clinical case. A clinical case of a patient with SLE with bilateral pneumonia, pleurisy, ascites, anemia, thrombocytopenia, generalized lymphadenopathy of the mediastinum, abdominal cavity and retroperitoneal space, hepato- and splenomegaly is presented. Based on the results of a sternal puncture, the patient was diagnosed with diffuse large B-cell lymphoma in the leukemic stage. Conclusions. The presence of SLE as a background disease creates problems for verifying the diagnosis of NL even in the terminal (leukemic) stage due to the similarity of clinical symptoms (fever, asthenic syndrome, joint pain, lymphadenopathy, presence of infectious complications) and changes in the general blood test (anemia, thrombocytopenia, increased ESR).
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