SKIN MANIFESTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS (CASE FROM CLINICAL PRACTICE)
Summary. Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease of unknown etiology that occurs at the background of genetic disorders of immunoregulatory processes and the influence of environmental factors and is characterized by the hyperproduction of organ-nonspecific autoantibodies to various components of the cell nucleus with the development of immunoinflammatory damage to tissues and internal organs. An important manifestation of SLE is the presence of skin lesions. There are several phenotypes of SLE with different clinical manifestations — from mild mucocutaneous to severe multiorgan lesions. Incidence and prevalence vary significantly in different regions of the globe, depending on sex, age, race, and ethnicity. For example, in different states of the USA, the incidence varies from 1.0 to 7.6 cases per 100 thousand population per year, and the prevalence — from 53.3 to 149.5 patients per 100 thousand population (on average — 81.1). In Great Britain these figures are 4.9 and 65.0, respectively. In Ukraine, as of 2017, the incidence was only 0.7 cases per 100,000 people, and the prevalence was 17.1 per 100,000 population, which is significantly lower than the global indicators . Goal. This article presents a description of a clinical case of skin manifestation of SLE in a 60-year-old man, with the aim of drawing attention to the importance of forehanded diagnosis of this pathology and differential diagnosis between cutaneous lupus and SLE. Conclusions. Subacute cutaneous lupus is one of the manifestations of SLE. Forehanded diagnosis of this disease requires a high degree of vigilance not only by a rheumatologist, but also by a dermatologist, a therapist, and a family doctor. A skin biopsy in the case of an atypical course of cutaneous lupus can be used for differential diagnosis with other skin diseases and SLE.
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