Рathogenetic role of the endothelial NO synthase (NOS3) and its influence in the development of the rheumatoid arthritis

Zaichko K.O., Stanislavchuk M.A.

Summary. This article summarizes a brief overview of the clinical research devoted to the pathogenetic role of the endothelial NO synthase (NOS3) and its influence in the development of the rheumatoid arthritis (RA). Modern information on the involvement of NOS3 in the regulation of angiogenesis, inflammation, bone remodeling is presented. The role of polymorphism of the NOS3 gene in the development of various pathological conditions is highlighted. The perspective of further researches on the clinical and pathogenetic role of polymorphism of the promoter of the NOS3 T-786C gene in patients with RA is shown.

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