INFLUENCE OF THE IMMUNE STATUS AND LIPID FACTORS ON SUBCLINICAL ATHEROSCLEROSIS PROGRESSION AND DEVELOPMENT OF THE CARDIOVASCULAR DISEASES IN PATIENTS WITH RHEUMATOID ARTHRITIS
Kovalenko V.N.1, Khimion L. , Lysenko G.I.2, Garmish O.O. 3
Summary. Summary. Objective. To investigate the influence of immune and lipid factors, use of different disease modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs) on the progression of subclinical atherosclerosis in patients with rheumatoid arthritis (RA) and their link to the development of cardio-vascular diseases in these patients.
Methods. The prevalence of traditional risk factors for the cardio-vascular diseases development; influence of the immune, cytokine, lipid factors, use of different DMARDs and NSAIDs at the progression of subclini-cal atherosclerosis and development of cardio-vas-cular diseases has been investigated in ISO RA patients
Results. It is shown that progression of subclini-cal atherosclerosis in RA patients has a different rate which depends on use an effectiveness of the DMARD and anti-inflammatory therapy, severity of the immunologic changes, activity of the immu-no-inflammatory process, endothelium activation and presence of the systemic signs.
Conclusion. In RA patients, premature accelerated atherosclerosis is a component of the systemic disease, more prevalent in non-responders to standard treatment with significant immunodeficiency which leads to the long term increase of circulating anticyclic citrulinated protein antibodies (antiCCPat), persistent high level of the systemic immuno-inflammatoryprocess, activation of en-dothelium and acceleration of atherogenesis, despite lower level of total cholesterol and low density lipoproteins (LDL). Accelerated atherosclerosis increases the risk of cardio-vascular diseases in RA.