BLOOD calprotectin (mrp-8/mrp-14) as sensitive diagnostic biomarker of systemic-onset juvenile idiopathic arthritis

Boyko Ya.E.

Summary. Systemic-onset juvenile idiopathic arthritis (sJIA) is a polygenic auto-inflammatory disease that manifests with arthritis, febrile peaks, erythematous rash, hepatosplenomegaly and serosites. Difficulties exist in establishing diagnosis in children in the initial stages of the disease, because there is a need to differentiate it with other diseases manifesting with pyretic fever. Identification of biomarkers of systemic arthritis in children, as one of the causes of FUO (fever of unknown origin), may help in early diagnostics of this disease and timely start of treatment. The results of conducted studies show that determination of blood MRP-8/MRP-14 levels (blood calprotectin) is helpful in diagnostics of juvenile systemic arthritis, which is extremely important in children with newly diagnosed JIA, and for differential diagnostics of diseases manifesting with pyretic fever. MRP-8/MRP-14 levels determination can be used to monitor subclinical activity of systemic arthritis and to identify patients having potential risk of disease exacerbation.

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