POSSIBILITY TO PREDICT THE DEVELOPMENT OF THE CARDIO- AND CEREBRO-VASCULAR COMPLICATIONS IN RHEUMATOID ARTHRITIS PATIENTS

Kovalenko V.N.¹, Lysenko G.I.², Khimion L. , Garmish O.O. ³

• ¹ГУ «ННЦ «Институт кардиологии им. Н.Д. Стражеско» НАМН Украины», Киев
• ²Інститут сімейної медицини Національної медичної академії післядипломної освіти ім. П.Л. Шупика МОЗ України
• ³ГУ «ННЦ Институт кардиологии им. Н.Д. Стражеско» НАМН Украины», Киев

Summary. Summary. Objective — to investigate the influence of immune and lipid factors, use of different disease modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs) on the progression of subclinical atherosclerosis in patients with rheumatoid arthritis (RA) and their link to the development of cardio-vascular diseases in these patients.
The significance of traditional cardio-vascular risk factors; different immune and cytokine factors; markers of inflammatory process and differences in RA pharmacologic treatment for prognosis of the cardio- and cerebro-vascular complications deve­lopment have been investigated in 180 RA patients younger then 50 years old.
The algorithm for prognosis of vascular complications development in RA patients has been developed.
In RA patients, premature accelerated atherosclerosis which is a component of the systemic disease, leads to significant increase in cardio- and cerebro-vascular events and diseases development, which can be predicted with the acceptable reliability using the prognostic algorithm proposed by authors.