Homenko V.M. 1, Bykov V.A.1, Ostapchuk O.I.1, Shkondina O.F.1, Stanislavchuk M.A.2

Summary. Fibromyalgia (FM) is a syndrome of chronic widespread musculoskeletal pain, which is accompanied by fatigue, anxiety, depression, sleep disorders, cognitive disorders and requires differential diagnosis with nosologies that have similar clinical symptoms. The purpose of the study: to conduct a comparative characterization of fibromyalgia and pathological conditions accompanied by chronic diffuse musculoskeletal pain according to literature sources. Research results: it was determined that establishing a diagnosis of primary fibromyalgia requires differential diagnosis with inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, polymyalgia rheumatica, etc.), endocrinopathies (hypothyroidism, hyperparathyroidism, Itsenko-Cushing syndrome), neuropathies (myofascial pain syndrome), infectious syndromes (post-covid syndrome, Lyme disease) and metabolic disorders. The presence of secondary fibromyalgia can alter the course of the underlying disease and the response to standard pharmacotherapy. Conclusions: the difficulty of differential diagnosis between FM and pathological conditions with chronic musculoskeletal pain is caused by the lack of standardized algorithms, which requires further research.

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