Features of physical development in children with juvenile idiopathic arthritis
Summary. Aim. To study the influence of the current course of juvenile idiopathic arthritis (JIA) on the physical development of sick children. Materials and methods. the statistical analysis of the physical development status in 67 children from 1 to 18 years old was conducted, using the correlation, multivariate parametric method, according to the medical documentation. Results. Among the examined children, no significant growth disturbances were noted. Body mass index did not differ from the norm for healthy children. No significant decrease in linear growth was observed in the examined children, which differed from those of previous researchers. The height of patients with JIA did not depend on the activity of the disease (r=–0.37). In long-term infants, JADAS27 was less likely to be administered to basic disease-modifying therapy (BDMT) for up to 3 months from the debut of the disease, an increase in the dose of methotrexate more conducive to the normalization of physical development, and the appointment of intraarticular injections of glucocorticoids (GC) does not have a significant effect on the rate of linear growth of the child. With high disease activity, the combination of BDMT + systemic GC in the first 6 months from the debut was worse than BDMT + adalimumab and BDMT + tocilizumab. Conclusions. In recent years, a decrease in the degree of growth retardation with systemic JIA (10.44%) in comparison with historical control (49%) is noted. The appointment of biological therapy leads to the fact that patients with a more unfavorable course have no greater degree of delayed physical development than patients with less aggressive course of the disease (which receive only BDMT).
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