MORPHOLOGICAL INDICES OF PATHOLOGICAL CHANGES OF THE HIP JOINT, THE FREQUENCY OF THEIR OCCURRENCE AND CORRELATIONS WITH INDICATORS OF FEMORAL HEAD SPONGIOSA HISTOMORPHOMETRY IN PATIENTS WITH RHEUMATOID ARTHRITIS
Hryhorovskyi V.V., Babko A.M., Gerasimenko A.S.
Summary. The purpose of this study was: using a system of semi-quantitative grading indicators of pathological changes in the tissues of the hip joint (inflammatory, dystrophic, reparative, etc.) and spongiosa histomorphometry (SHM) to determine the frequency of occurrence of certain gradations and correlation links between individual indicators of the joint capsule and femoral head in patients with rheumatoid arthritis (RA), whom were removed fragments of the affected joints. The material of the study were bone and soft tissue fragments of hip joints of 20 patients with RA. As a result of histological examination, a number of non-parametric morphological indices were determined. SHM of the femoral head included four indicators reflecting various quantitative properties of spongiosa. Results. Some histological changes were found in the hip joint tissues, which reflect a variety of pathological processes: chronic productive inflammation with the immune component, hypertrophic proliferations of the synovial layer of the joint capsule, dystrophic-destructive changes. The grades of morphological indicators vary from case to case and may correlate differently between themselves and with the parameters of the SHM-indicators. Conclusion. Between the morphological indicators of the state of the hip joint tissues: synovial layer of the capsule, articular cartilage, subchondrial bone plate and bone marrow, on the one hand, and SHM-indicators of the state of the femoral head spongiosa, on the other hand, exist some correlations, based on which the severity of some tissue state indicators can be predicted for others, well-known indicators of damage.
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