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FEATURES OF INTERACTION OF AUTOANTIBODIES TO EXTRACTED NUCLEAR ANTIGENS AND SCREENING AUTOANTIBODIES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Summary. Systemic lupus erythematosus (SLE) is characterized by multiple autoantibodies. Anti-double-stranded DNA (dsDNA) antibody titers may vary over time and after immunosuppressive treatment, while the behavior of anti-extractable nuclear antigen (ENA) over time is less well understood. Аim. The article describes results of researches of correlation of autoantibody ЕNА profile (anti-Ro, anti-La, anti-RNP, anti-Sm) with screening tests (ANA, anti-dsDNA) in patients with SLE. Materials and Methods. In the submitted study in 105 patients with SLE autoantibodies were evaluated and different subgroups of SLE were assessed. Associations of autoantibody activity of the disease expressed by the SLEDAI and BILAG (Systemic Lupus Erythematosus Disease Activity Index and British Isles Lupus Assessment Group). Serologic tests included ANA, anti-dsDNA, anti-Smith, anti-ribonucleoprotein (RNP), anti-Ro, anti-La immunoferment analysis. Results. Positive result of the antinuclear antibody (ANA) was found in 85 (81.0%) patients. A positive antibody titers to RNP was recorded in 18 (32.2%) patients, profile anti-DNA was found in 91 (86.6%) patients, 23 (51.0%) patient had titers anti-SS-A, and 25 (50.0%) patients had titers anti-SS-B. Antibody titers Sm were found in the group of 18 (30.0%) patients. Using regression analysis and Pearson’s correlation coefficient correlations were found between anti-RNP values and SLEDAI (r=0.57, p<0.01), anti-RNP and BILAG (r=0.60, p<0.01). Conclusion. The study shows that evaluation of antinuclear antibody levels in SLE is important not only for the diagnosis establishment and its activity but also for prediction of development complication SLE.
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