Features of immune response in patients with ankylosing spondylitis
Summary. Ankylosing spondyloarthritis (AS) — a chronic rheumatic inflammatory disease refers to a group of seronegative spondylitis with common clinical, serologic, genetic traits and lead to a lesion mobility of the spine with the subsequent development of ankylosis. Significant role in the pathogenesis of AS immune cells play as congenital (neutrophils, monocytes/macorophags, dendritic cells) and acquired immunity (T- and B-lymphocytes). Immune cells are part synovium and involved in inflammation, capturing the surrounding tissue, which leads to joint damage. The result of the activation of immune cells is secretion of proinflammatory cytokines, including TNF-α. Inflammatory cytokines stimulate synovial fibroblasts and other cells to secrete VEGF.
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