The features of immune response in patients with heart failure

Fedorov S.V., Glushko L.V.

Summary. Summary. The aim of study was to evaluate of character and stage of immune changes in patients with ischemic heart failure (HF). 389 patients with HF FC ІІ–IV (NYHA) were observed. The immunological investigation consist of detection of main and activated populations and subpopulations of lymphocytes by indirect immunofluorescent method and serum immunoglobulin’s level by ELISA. In patients with ischemic HF we established of CD8+-lymphocyte count decrease and increase of CD19+-cells and activated subpopulations of lymphocytes (CD25+, CD95+). The decrease of serum levels of IgA, IgG and IgM were detected which was more significant at the terminal stages of this syndrome. The HF progression caused of strong disturbances which could shown as secondary immunodeficiency.

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