Syniachenko O.V.1, Bevzenko T. B., Iermolaieva M.V.1, Dyadyk O.I. 2

Summary. The aim of the work. To conduct a comparison of the nature of renal disease with the clinical course of hemorrhagic vasculitis, to assess the correlation between extrarenal manifestation of disease with morphological features of glomerulonephritis. Materials and methods. The study included 144 patients with Wegener’s granulomatosis (56% of men and 44% of women). In 21 patients (12 men and 9 women) with preserved renal function and urinary syndrome are performed in their lifetime morphological study of renal tissue. As a whole, GN was diagnosed in 65% of patient population, chronic renal failure I–IV degree — in 17%, nephrotic syndrome — in 8%. The morphological class GN was bigger in men. Results. According to the results of variance and correlation analysis activity of HV, integrated severity of extrarenal manifestations of the disease, the severity of cardiac pathology influence on the incidence of GN, and glomerular filtration rate depends on the parameters of anti-neutrophil cytoplasmic antibodies, effective renal plasma flow depends on the levels of immunoglobulin (Ig) M and circulating immune complexes, renal vascular resistance — on the content of IgG, and fibrinogen, fibronectin, C-reactive protein and IgA level in blood depend on the changes in the kidneys. Conclusions. When GW clinic-pathologic character of kidney damage in HV as GN correlated with extrarenal manifestations of the disease, the degree of disease activity and the concentration of immune inflammatory proteins in blood.

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