Personalized approach to the management of osteoarthritis and osteoporosis: the key role of mineral balance in treatment and prevention

The editors of the «Ukrainian rheumatological journal»

Summary. Osteoarthritis (OA) and osteoporosis (OP) are the two most common diseases of the musculoskeletal system, which often coexist and mutually worsen each other. Modern approaches to the management of these conditions emphasize the need for personalized strategies that take into account the clinical phenotype, metabolic status and structural changes. One of the key factors influencing the course and prognosis of OA and OP is the state of mineral balance, primarily adequate calcium intake. Optimal calcium levels play a critical role in maintaining bone density, maintaining subchondral bone and indirectly affecting cartilage metabolism, making it an important component of the comprehensive treatment of OA. Calcium deficiency and secondary hyperparathyroidism can accelerate the structural progression of OA and worsen the clinical course of OA. At the same time, correction of hypocalcemia, especially with bioavailable calcium salts in combination with vitamins D and K₂, contributes to improving bone mineralization, reducing the risk of fractures and optimizing the results of therapy. Thus, restoring mineral homeostasis is a necessary component of a personalized management strategy for patients with OA and OA, enhancing the effectiveness of both pharmacological and non-pharmacological interventions.