Kuzmina G.P., Lazarenko O.M.

Summary. Antiphospholipid syndrome (APS) is an autoimmune thrombophilia caused by circulating antiphospholipid antibodies (aPL) that favors the development of thrombotic events. In addition to acute thrombosis, patients with APS may also develop occlusive vasculopathy. The long-term consequences of APS are characterized by cellular proliferation and infiltration, which gradually increases and leads to organ damage. The goal was to evaluate thrombotic events associated with APS, to analyze the pathogenetic mechanisms of their occurrence based on the analysis of literature data. Materials and methods: an analysis of literature data was conducted based on a search of English-language articles in the Medline and PubMed databases that were published from January 2020 to June 2023. The article presents an analysis of the main diagnostic markers of APS in view of their role in pathogenesis, as well as the prospects for the use of new ones discovered in recent randomized trials.

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