THE USE OF NSAIDS IN CHRONIC KIDNEY DISEASE: FEASIBILITY AND SAFETY PROFILE MANAGEMENT
Summary. Chronic kidney disease (CKD) is often accompanied by the development of pain of various etiologies. The pain may be ischemic, musculoskeletal, neuropathic, or renal osteodystrophy. Depending on the cause of the pain syndrome, it is necessary to select the optimal medicine for its relief. Unfortunately, patients with CKD often do not receive proper treatment for pain due to warnings about worsening their underlying disease. Methods. A review of the literature and information on the possible risks of using various non-steroidal anti-inflammatory drugs (NSAIDs). Results and discussion. This review considers possible approaches to pain relief in patients with CKD and approaches aimed at optimizing the safety profile of the selected therapy. Conclusions. Diclofenac with a shorter half-life deserves attention in CKD along with dose adjustment.
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