ISCHEMIC AND NON-ISCHEMIC HEART LESIONS IN PATIENTS WITH RHEUMATOID ARTHRITIS. II. INFLUENCE OF TREATMENT ON THE DEVELOPMENT OF HEART DISEASE IN RA

Uzun K.S.¹, Gnylorybov A.M.², Batushkin V.V.¹, Uzun D.Yu.²

• ¹Kyiv Medical University
• ²National Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine named after M. Amosova

Summary. The paper analyzes the impact of drug treatment and its strategies on the risk of cardiovascular disease in patients with rheumatoid arthritis. It has been shown in recent years that the risk of cardiovascular lesions in rheumatoid arthritis has been reduced by improving rheumatoid arthritis treatment strategies («treat-to-target strategy»). However, despite the improvement of antirheumatic drugs, many patients with rheumatoid arthritis still show high disease activity. Further research should focus more on targeted cardioprotective therapy for patients with rheumatoid arthritis with high disease activity and those with heart failure. Achieving treatment goals requires a better understanding of the pathophysiological processes associated with rheumatoid arthritis that contribute to heart failure. Unfortunately, the underlying cellular and molecular mechanisms of pathogenesis remain unclear. Additional clinical and experimental studies are needed to identify new therapeutic goals and to develop successful cardioprotective treatments for RA patients.