Clinic-pathogenetic significance of changes in purine exchange of gout present-day course

Syniachenko O.V.1, Bryzhataja J.O.2, Yakubenko O.D.2

Summary. Summary. The aim and tasks of the study is to carry out the evaluation of clinical-pathogenetic significance of changes in purine exchange with different forms of gouty arthritis and nephropathy courses. Material and methods. There have been examined 89 patients with primary gout; intermitting type of arthritis has been set in 63% of cases, chronic one — in 37%, urolithiasic type of nephropathy in 39%, latent in 61%, diminished kidney function has been set in 54% of the examined patients, light clinical course of articular syndrome took place in 19% of cases, moderately severe — in 51% and severe — in 30%. Results and their consideration. According to the multifactor variance analysis data integral changes in purine exchange depend upon the sex of gouty patients, the character of articular syndrome course and nephropathy type, renal failure presence, arterial hypertension, osseous tophi, subchondral sclerosis, epiphysical osteoporosis and osteocystose, and single indices correlate with patients’ age, duration of disease, depend on arthritis forms and renal pathology. Conclusions: the parameters of purine exchange are closely connected with the single signs of gout, have prognostic significance, take part in pathogenesis of osteo-destructive lesions of articulations and in the changes of electrolytosecretory function of kidneys.

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