clinical and radiological associations in different Variants of disease modifying therapy of rheumatoid arthritis

Iaremenko O.B. , Mikitenko G.M.

Summary. Summary. In this clinical study the relationship between the clinical efficacy of the main non-biological disease modifying antirheumatic drugs (DMARDs) or their combinations (CBT) and dynamics of radiological changes in patients with rheumatoid arthritis (RA) were analyzed. It is shown that 2 years treatment with leflunomide (LF) or CBT exerts more pronounced effect on decrease of clinical activity and slowing-down of joint destruction compared to methotrexate (MTX) in average doses or sulfasalazine (SS). In general cohort of patients the achievement of moderate/good response to treatment or remission by DAS28 was associated with significantly less radiographic progression compared with non-responders. However, the frequency of radiological remission did not dependent on clinical response. There is an inverse moderate correlation between the dynamics of the clinical activity (ΔDAS28) and the radiographic progression of RA with significant scattering of radiological progression in patients with different DAS28 dynamics. Unlike MTX, LF and CBT in the treatment of SS there is no relationship between clinical efficacy and radiological improvement.

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