Metabolic disorders in patients with psoriatic arthritis

Bortkevych O.P. ¹, Sydorenko D.M.¹, Krylova A.S.², Radchenko G.D. ¹

• ¹SU «National Scientific Center «Institute of Cardiology, Clinical and Regenerative Medicine named after Academician M.D. Strazhesko of the National Academy of Medical Sciences of Ukraine», Kyiv
• ²Shupyk National Healthcare University of Ukraine, Kyiv

Summary. Psoriatic arthritis (PsA) is a chronic immunoinflammatory disease that is often associated with metabolic disorders, including hyperuricemia and dyslipidemia, which plays an important role in increasing cardiometabolic risk and potentially affects the course of the disease. Objective. To study the features of metabolic disorders in patients with PsA depending on the presence of hyperuricemia and the type of basic therapy (synthetic, biological, combined), as well as to assess the relationship between lipid parameters, inflammatory markers and liver function. Materials and methods. We examined 98 patients with psoriatic arthritis. All patients underwent a general clinical examination, biochemical blood tests to determine the lipid profile, liver enzymes, C-reactive protein, and uric acid levels. Statistical analysis included comparison of intergroup differences and correlation analysis (significance level p<0.05). Results. Hyperlipidemia was detected in 52% of patients, hyperuricemia — in 30%, steatohepatosis — in 22.4%. In the study of correlations, a statistically significant correlation was found between uric acid parameters and triglyceride levels (r=0.52) p≤0.000001, an inverse correlation with HDL cholesterol levels (r=-0.44) p≤0.000005, and no correlation was found with cholesterol and LDL cholesterol levels according to Spearman’s criterion. We also obtained a weak statistical relationship between triglyceride levels and ALT (r=0.3) p≤0.0002, AST (r=0.21) p=0.029, CRP (r=0.38) p=0.000115, a weak statistical inverse relationship between HDL-C and ALT (r=-0.35) p≤0.001, AST (r=-0.25) p=0.027, and CRP (r=-0.21) p=0.034 The lowest levels of cholesterol, triglycerides and LDL-C were in the combination therapy group. Conclusions. Patients with psoriatic arthritis have a high level of metabolic disorders, including hyperlipidemia (52%), hypertension (39.7%), hyperuricemia (30%) and liver dysfunction (22.4%). Statistically significant correlations were found between lipid profile components and inflammatory biomarkers and liver enzymes. The use of combined basic therapy (biological + synthetic) was associated with more favorable lipid profile parameters.