Number№82 (4) 2020

HORMONAL-METABOLIC STATUS OF PRE- AND POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES MELLITUS

Zhuravlyova L.V., Cherpita V.O.

Summary. Type 2 diabetes mellitus is one of the most common chronic diseases of our time, and which has recently been recognized as a social problem, and which is becoming more and more significant. The purpose of the review is to summarize current information on the development of type 2 diabetes mellitus in pre- and postmenopausal women, to determine the hormonal and metabolic status of pre- and postmenopausal women with type 2 diabetes mellitus. Relevance. The number of people with type 2 diabetes mellitus with the development of various complications is increasing every day. This primarily leads to a reduction in the life span and a decrease in the comfort of human life. Type 2 diabetes mellitus is the main risk factor in the occurrence of cardiovascular pathology, which is the leading cause of death in developed countries. Therefore, type 2 diabetes mellitus is highly detrimental to women’s health, especially during the pre- and postmenopausal period. This fact requires prevention and early diagnosis of type 2 diabetes mellitus. The termination of ovarian function with an inevitable decrease in the biosynthesis of female sex hormones is accompanied by mandatory hormonal changes in the woman’s body, and causes changes primarily in metabolic metabolism. Results. Based on the processing of modern literary sources on this issue, it was proved and summarized that in the development of type 2 diabetes mellitus in women, the inevitable onset of menopause occupies a special place among all the various risk factors, and it is menopause that provokes further progression of type 2 diabetes mellitus. And therefore, it is the deficiency of estrogen that should be considered as one of the main pathophysiological components in metabolic disorders in the body of a woman with the onset of menopause.

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