Lukyanchuk E.

Summary. Gout is a systemic tofus disease characterized by the deposition of sodium monourate crystals. One of the main manifestations of gout is arthritis, which is manifested by pain and swelling of the joints. Treatment of gout includes treatment of acute gout attacks and their prevention. According to the EULAR guidelines of 2016, complex treatment with colchicine and/or nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids is recommended as first-line therapy. It is shown that the use of NSAIDs in an attack of acute gouty arthritis in more than 90% of cases leads to complete pain relief within 5–8 days. In this context, the use of selective COX-2 inhibitors may have some advantages over non-selective NSAIDs. One of the promising drugs to relieve pain in gout is nimesulide. The article presents an overview of the literature on the main aspects of the effectiveness and safety profile of the drug nimesulide in acute gouty arthritis. Nimesulide is an effective even when treatment with other NSAIDs has been ineffective. Nimesulide in this case allows to achieve a twofold reduction in the severity of pain in patients within 5 days after the replacement of ineffective NSAIDs with nimesulide. Thus, nimesulide is an effective drug with good tolerability, which effectively relieves gout.

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