Syniachenko O.V.1, Sokrut N.V.2, Iermolaieva M.V.1, Klimovitskiy F.V.2

Summary. Actuality. Gonarthrosis is one of the most common diseases rheumatologic and orthopedic profile, which causes a significant health and social damage either to the people with illness or to society as a whole. Gonarthrosis is accompanied by microelementosis proceeding with a violation of in the body levels of many essential and toxic metals. After endoprosthesis replacement of knee joints in the body of patients does the content of such metals as Co, Cr, Ti, and others which are able to determine the «durability» of the graft prosthesis and the further course of gonarthrosis. The purpose and objectives of the research — to determine levels of metals included in the composition of total knee joints (Al, Co, Cr, Fe, Mo, Ni, Ti, V) in patients with gonarthrosis, as well as compare the values with concentrations of these trace elements in the hair, to evaluate the clinical and pathogenetic significance of this microelementosis with different variants of disease course. Materials and me­thods. Were examined 87 patients with gonarthrosis (45% men and 55% women with an average age of 53 years). I, II and III stages of the disease respectively identified in 28; 41 and 31% of observations, polyarthrosis occurred in 53% of cases, osteochondrosis is 92%, spondiloarthrosis of bootastic joints in 71%, clinically symptomatic synovitis (drive) — 67%. To study the performance of metals in the organism were used atomic absorption spectrometer «SolAAr-Mk2-MOZe» with electrographite atomizer (UK). Results. Microelementhosis in the blood of patients with gonarthrosis observed in 41% of cases, while in the hair is 23%, which is accompanied by increased levels of Ti and V in the serum on the background of reducing the concentration of Fe that isaccordingly observed in 40; 44 and 43% of patients, and the hair changes of metals are related to the increasing content of Al, Fe and Ti with decreasing parameters of Co, Cr and Mo in 46; 100; 22; 12; 29 and 45% of cases. It depends on the radiographic stage of the disease, the presence of synovitis, the prevalence and severity of articular syndrome. Microelementhosis involved in the pathogenesis of lesions of the meniscus, bursitis, trabecular oedema in the patella, forming osteophytes, osteocytes and intraarticular Shtydy bodies, which is correlated with osteoporosis (Al, Co, Cr, Ni), values of Cr, Ti and V in different objects of study (blood, hair) are correlated to each other, as well as have prognostic significance. Conclusions. Gonarthrosis courses with changing le­vels of metals in blood and hair (Al, Co, Cr, Fe, Mo, Ti, V) contained in the total knee joints, which depends on the clinical course of the disease, determines the pathogenetic compositions of articular degenerative inflammatory lesions and forces the necessity of the microelements study in the body of patients in the process of dynamic observation after joint replacement.

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