The investigation of efficacy of selective nonsteroidal anti-inflammatory drugs in patients with osteoarthritis

Shuba N.M. 1, Voronkov L.G. 2, Voronova T.D.1, Pilipenko A.V.1, Gulenko O.I.1, Litvinenko S.V.1

Summary. Comparative description of mostly widespread drugs from the group of selective non-steroidal anti-inflammatory drugs, in particular nimesulide and meloxicam is presented in the article. The data received have demonstrated advantages of nimesulide, namely fast clinical efficacy, anti-inflammatory action compare to meloxicam, reduce of nitric oxide level, which prove decrease of inflammation activity and cartilage degradation and also acceptable safety profile during 2 weeks of administration. This allow recommend it as a drug of choice in pain syndrome management.

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