Non-invasive investigation of the complex of the intima-media of the carotid arteries in patients with rheumatoid arthritis

Zakrytov D.A.

Summary. Summary. The aim of the study was to assess the thickness complex intima-media (СIM) in patients with rheumatoid arthritis (RA) and to identify the relationship of risk factors that contribute to the development of atherosclerosis and specific parameters of RA. It was studied 115 patients with RA. The study was conducted in accordance with the Protocol of examination of RA patients. It was conducted duplex scanning of the brachiocephalic vessels. Assessment of risk factors for fatal cardiovascular events caused by atherosclerosis, was assessed using the scale SCORE. СIM changes write my essay for me were revealed in 80% of patients with RA. It was revealed a clear dependence of the СIM thickness not only from the traditional factors of cardiovascular risk, but also from specific parameters of RA activity by DAS28, the index of the HAQ disability, the level of С-reactive protein in blood serum. It is known that for the occurrence of inflammation requires the formation of cytokines, growth factors, endothelial, and other proinflammatory mediators, with subsequent activation and deposition of complement components, leading to activation and proliferation of endothelial and smooth muscle cells of the vascular wall and plays an important role in atherosclerosis. In this regard, RA can be considered as an independent risk factor for cardiovascular events in the development of atherosclerosis, it enables the use of СIM measurement as early diagnosis of atherosclerosis in patients with RA.

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