METABOLISM OF NITROGEN OXIDE IN SLE-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION

Klekot O.O.

• National Pirogov Memorial Medical University, Vinnytsya

Summary. This study describes the features of Nitrogen oxide metabolism in pulmonary arterial hypertension in patients with systemic lupus erythematosus (SLE). Despite the elevated levels of nitrates and nitrites in the blood of patients with SLE (on 20% higher than in the control group), an active pool of Nitrogen Oxide, S-nitrosothiols presented, is fairly low, compared with healthy people (1.7±0.4 and 2.08±0.4 mc-mol /1, respectively). Deficiency of S-nitrosothiols in SLE (-24%) significantly increased during the development of pulmonary hypertension (p<0.001).