Number№82 (4) 2020

ROLE OF LEPTIN IN THE PATHOGENESIS OF OSTEOARTHRITIS IN ASSOCIATION WITH OBESITY

Prystupa L.N. , Opimakh O.I.

Summary. The article phone spy introduces a scientific literature analysis on the role of leptin hyperoutput in pathogenesis of osteoarthritis in association with obesity. Lep-tin's impact on inflammatory and degenerative processes is considered, when obesity is associated with osteoarthritis. Leptin is proven to be the key regulator in chondrocytes metabolism, the link between obesity and osteoarthritis through inflammation, as well as the ground for gender distinctions of the disease.

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