AGE AND SEXUAL DIFFERENCES OF SPONDYLOARTHRITIS

Iaremenko O.B., Shynkaruk Iu.L., Fedkov D.L. , Mazanko K.V.

• National Medical University O.O. Bogomolets, Kyiv

Summary. The study included 102 patients with spondyloarthritis (SpA). There were analyzed the frequency of the forms of SpA, HLA-B27 status, the disease duration, the course of SpA depending on the radiographic sacroilеitis grading, the functional status (index BASFI), disease activity (according to the level of inflammatory markers and indices — BASDAI, ASDAS), and inflammatory changes in the sacroilial joints according to magnetic resonance imaging (SPARCC score) among males and females in formed groups (І, ІІ and ІІІ+IV quartiles) depending on SpA onset age. In case of SpA onset at age less than 35 years, especially in women, peripheral SpA was more common, whereas in case at the older age onset, more than half of patients of both sexes had axi­al SpA. In general, peripheral SpA in women deve­lops more often compared to men (ratio with the central 2.5: 1 and 1.2: 1, respectively). Most SpA patients were HLA-B27-positive, and more often had sacroiliitis grade 2, regardless of sex and age of SpA onset. Early onset of SpA up to 23 years was associated with the lowest levels of laboratory markers of inflammation and slower radiological sacroilеitis progression. The highest ESR levels were found in individuals with the disease onset after 35 years, and CRP — in men with SpA onset at the age of 23–35 years. In gene­ral, patients with disease onset up to 23 years had the lowest levels of laboratory markers of inflammation, and CRP level in male patients was 2.6 times higher than in female. There were no differences between males and females depending on the age of SpA onset. There were no significant differences according to the sex and age of SpA onset by clinical indices and inflammatory score of sacroiliac joints.