Syniachenko O.V.1, Dumanskiy Yu.V.1, Stoliarova O.Yu.2, Stepko P.A.1, Yehudina Ye.D.3

Summary. The frequency of metastatic lesions of various parts of the spine, peripheral bones and joints, the connection between clinical signs of lung cancer (localization, shape, histology, degree of differentiation, staging, character extraosseous metastases), the evaluation of depending on comorbidities, the impact on complications from radiotherapy and chemotherapy, as well as survival were investigated. The study included 1071 patients with lung cancer at the age of 24 to 86 years. None of the examined patients has been operated previously on account of the underlying disease, all patients received radiation therapy after establishment of the diagnosis, 73% of them recieved combined radiochemotherapy. Metastatic lesion of skeleton is observed in 22% patients with lung cancer, among them the ratio of the spine’s alteration, peripheral bone’s and joints’ is 2:2:1 correspondingly and also in 3% of these patients is marked the tumor invasion into the ribs, on which generally the localization of cancer (mainly in the upper lobe), its form (mainly peripheral) and histology variant (predominantly adenocarcinoma) have an influence, which is associated with other clinical manifestations of the disease (the presence of compression syndrome and tumor invasion into the trachea with one hand and metastases in the spine, hip bone and jaw on the other), with the level of osteoassociated markers in the blood, correlates with the number of metastases in the lymph nodes and organs, depends on concomitant pathologies, influences on the character of complications from radiochemotherapy and certain anticancer drugs. The so-called «osteo-articu­lar form» of the lung cancer is characterized by the greater degree of severity of the disease, determines the survival of the patients, requires correction of the drug chemotherapy.

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