Importance and principles of pharmacological correction of renin- angiotensin system in the treatment of atrial fibrillation

Getman T.V.

Summary. Summary. The purpose of this study was to investigate the influence of concomitant therapy with lisinopril on morphological and functional characteristics of patients with atrial fibrillation. The study of 46 patients, aged 50 to 70 years (mean age 57.4±1.82 years) with the following diagnoses: coronary heart disease (stable exertional angina I–III functional class) (80.7% of patients), heart failure, I–IIA Art. (90.3% of patients), hypertensive heart disease I–II degree (87.1%), miokardiofibroz (12.9%). Heart rhythm disorders were: supraventricular beats in 19.6%, paroxysmal and persistent AF in 47.8%, a permanent form of AF in 32.6% of patients. All patients received basic treatment to which was added lisinopril. All studies were performed twice: on admission of the patient to the hospital and after 4 weeks of treatment with lisinopril. The study found that lisinopril favorable effect on LV diastolic function. Significant decrease in the values corrected Q–T interval and Q–T dispersion effect of lisinopril can bind with its positive effects on the autonomic regulation of the heart. 4-week taking the drug has a positive effect on the average, maximum and minimum values ​​of blood pressure, both systolic and diastolic blood pressure monitoring at.

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