Joints erosive and destructive changes in patients with earlier rheumatoid arthritis: approaches to the disease course prediction

Rekalov D.H.

• Zaporizhzhya state medical university

Summary. 183 patients with earlier rheumatoid arthritis were examined, including laboratory investigation parameters, which characterized joint inflammation and joint destruction. The association between laboratory parameters changes and joint destruction according radiological investigation was established. It was revealed that basic serum levels of C-telopeptide I and II are predictors of changes in the joint structure and matrix metalloproteinase-3 level is associated with joint inflammation.