MICROCHIMERISM. I. POSSIBLE SOURCES AND ROLE IN AUTOIMMUNE DISEASES
Grin V.K. , Gnilorybov A.M., Ivaschenko Yе.S., Trubnikova N.N. , Melokhina V.A. , Polulyakh O.Y. , Ridzhok V.V.
Summary. Abstract. The article discusses the new phenomenon in modern medicine and rheumatology which is microchimerism. It shows the history of micro-
chimerism research, its possible sources, types (fetal, maternal, etc.) its role in the development of certain autoimmune and rheumatic diseases, the mechanisms of influence on the course of the pathological autoimmune processes. Separately the latest data on detection microchimera and its cellular composition in some diseases (systemic sclerosis, lupus, dermatomyositis, diabetes mel-litus type 1, malignancies). It is shown that important in the development of rheumatic diseases may belong to «close» HLA-phenotypes of host and donor microchimeric cells that leads to the development of the reaction, reminiscent of chronic «graft-versus-hostdisease». Perhaps the belonging of microchimeric cells to specific types (such as T-lymphocytes) is of special value. The authors discuss the possible therapeutic use of chimerism for the induction of immunological tolerance and cancer treatment.