CLINICAL AND ANAMNESTIC CHARACTERISTICS AND PECULIARITIES OF HOMOCYSTEINE METABOLISM IN WOMEN WITH TYPE 2 DIABETES MELLITUS AND OSTEOARTHRITIS IN THE PRE- AND POST-MENOPAUSE PERIODS

Cherpita V.O.

• Kharkiv National Medical University, Kharkiv, Ukraine

Summary. The aim. To identify clinical and amnestic characteristics and features of homocysteine ​​metabolism in women with type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) in pre- and postmenopause. Materials and methods. 120 pre- and postmenopausal women were examined: 1 group — women with T2DM; Group 2 — women with OA; Group 3 — women with comorbid pathology (T2DM + OA). The control group consisted of 16 healthy women. Determination of the level of total human homocysteine ​​in the serum of patients was performed by enzyme-linked immunosorbent assay on the analyzer «Labline-90». Results. The article established the relationship between OA and T2DM with risk factors for their development (impaired glucose metabolism, hormonal changes in women during menopause, obesity) and the resulting disorders of the autonomic nervous system, manifested by increased systolic and diastolic blood pressure and disorders of homocysteine ​​metabolism. It was determined that the levels of menopausal index are significantly higher in persons with OA and T2DM (30.5±15.9 and 25.0±13.1 points, respectively) and in women with their comorbid course (21.7±13.0 points) compared with the control group (19.3±11.7 points). Presence of metabolic disorders in pre- and menopausal women under the influence of OA and T2DM with probable (<0.001) increase in homocysteine ​​levels in the presence of osteoarthritis (12.5±2.3 mmol/l), T2DM (15.0±3.4 mmol/l) and their comorbid combination (23.6±6.1 mmol/l) compared with the levels of healthy women in the control group (7.8±2.2 mmol/l)). Conclusions. Hyperhomocysteinemia is considered by many scientists as a risk factor for systemic atherosclerosis, cardiovascular and neurological diseases and stroke, etc., as evidenced by many epidemiological studies that show its close relationship with these complications. We have shown an increase in homocysteine ​​(HC) levels in patients with T2DM in combination with OA in pre- and postmenopausal women compared with the control group.