Antisynthetase syndrome: diagnostic and treatment peculiarities

Sirenko Yu.M.¹, Protsenko G.O.², Boychuk N.S.³

• ¹ДУ «Національний науковий центр «Інститут кардіології ім. М.Д. Стражеска» НАМН України», Київ
• ²State Institution National Scientific Center «Institute of Cardiology named after acad. M.D. Strazheska» National Academy of Medical Sciences of Ukraine
• ³ДУ «ННЦ «Інститут кардіології ім. М.Д. Стражеска НАМН України»

Summary. Summary. The antisynthetase syndrome is a rare disease of unknown etiology which is the most severe subtype of polymyositis/dermatomyositis (PM/DM). The hallmark of the disorder is the presence of serum antibodies which recognize the aminoacyl-tRNA synthetases, which play a vital role in protein synthesis. The clinical picture is characterized by acute onset, presence of PM/DM, interstitial lung disease, Raynaud’s phenomenon, articular involvement. The clinical case with ACC is proposed.