FEATURES CLINICAL SYMPTOMS WAYS AND CORRECTION GONARTHROSIS AT REDUCED BONE MINERAL DENSITY

Shuba N.M. ¹, Tarasenko T.N. ²

• ¹National Medical Academy of Postgraduate Education named after P.L. Shupik, Kyiv
• ²Національна медична академія післядипломної освіти ім. П.Л.Шупика

Summary. Summary. The purpose of the investigation was to study the clinical manifestations of gonarthrosis in patients with decreased bone mineral density and to clarify the optimal treatment of this patients category. 120 patients with osteoarthritis of the knee joints II–III radiological stages by Kellgren-Lawrence were examined, of which 54.2% ha low mineral bone mineral density (BMD). Depending on the therapy patients were divided into 4 groups. First group took chondroitin sulfate (CS)-4,6 1g per day for 6 months and nimesulide 200 mg per day to 15 days. Patients of second group received CS- 4,6 1 g per day for 6 months and diclofenac 150 mg per day to 15 days. Patients of third group received nimesulide 200 mg per day to 15 days. Patients of fourth group received diclofenac 150 mg per day to 15 days. Сorrelations between BMD and clinical and laboratory parameters were revealed. The features gonarthrosis course in patients with decreased bone mineral density: more severe pain, limitation of functional activity and elevated levels of CRP. Аfter 6 and 12 months significantly less decline in BMD (T- and Z-index in standard deviations) was found in the groups, the patients who received CS-4,6, which allows to conclude that the positive effect on BMD.